beta-Cyclodextrin → HCID 131732184, compound

HRID 1404848Notes

Reaction equation

HRID 1404848 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][N:5]2[C:10]3[C:11]4[NH:42][C:40](=[O:41])[C:39]([CH3:43])=[CH:38][CH:37]=[CH:36][C@H:35]([CH3:44])[C@H:34]([OH:45])[C@@H:33]([CH3:46])[C@@H:32]([OH:47])[C@@H:31]([CH3:48])[C@H:30]([O:49][C:50]([CH3:52])=[O:51])[C@H:29]([CH3:53])[C@@H:28]([O:54][CH3:55])[CH:27]=[CH:26][O:25][C@:22]5([CH3:56])[C:23](=[O:24])[C:15]6=[C:16]([O:21]5)[C:17]([CH3:20])=[C:18]([OH:19])[C:13](=[C:14]6[C:9]=3[N:8]=[C:6]2[CH:7]=1)[C:12]=4[OH:57].[CH2:58]([OH:134])[C@H:59]1[O:64][C@@H:63]2[O:65][C@H:66]3[C@H:71]([OH:72])[C@@H:70]([OH:73])[C@@H:69]([O:74][C@H:75]4[C@H:80]([OH:81])[C@@H:79]([OH:82])[C@@H:78]([O:83][C@H:84]5[C@H:89]([OH:90])[C@@H:88]([OH:91])[C@@H:87]([O:92][C@H:93]6[C@H:98]([OH:99])[C@@H:97]([OH:100])[C@@H:96]([O:101][C@H:102]7[C@H:107]([OH:108])[C@@H:106]([OH:109])[C@@H:105]([O:110][C@H:111]8[C@H:117]([OH:118])[C@@H:116]([OH:119])[C@@H:114]([O:115][C@H:60]1[C@H:61]([OH:133])[C@H:62]2[OH:132])[O:113][C@@H:112]8[CH2:120][OH:121])[O:104][C@@H:103]7[CH2:122][OH:123])[O:95][C@@H:94]6[CH2:124][OH:125])[O:86][C@@H:85]5[CH2:126][OH:127])[O:77][C@@H:76]4[CH2:128][OH:129])[O:68][C@@H:67]3[CH2:130][OH:131]>C(O)C>[CH3:1][C:2]1[CH:3]=[CH:4][N:5]2[C:10]3[C:11]4[NH:42][C:40](=[O:41])[C:39]([CH3:43])=[CH:38][CH:37]=[CH:36][C@H:35]([CH3:44])[C@H:34]([OH:45])[C@@H:33]([CH3:46])[C@@H:32]([OH:47])[C@@H:31]([CH3:48])[C@H:30]([O:49][C:50]([CH3:52])=[O:51])[C@H:29]([CH3:53])[C@@H:28]([O:54][CH3:55])[CH:27]=[CH:26][O:25][C@:22]5([CH3:56])[C:23](=[O:24])[C:15]6=[C:16]([O:21]5)[C:17]([CH3:20])=[C:18]([OH:19])[C:13](=[C:14]6[C:9]=3[N:8]=[C:6]2[CH:7]=1)[C:12]=4[OH:57].[CH2:124]([OH:125])[C@H:94]1[O:95][C@@H:96]2[O:101][C@H:102]3[C@H:107]([OH:108])[C@@H:106]([OH:109])[C@@H:105]([O:110][C@H:111]4[C@H:117]([OH:118])[C@@H:116]([OH:119])[C@@H:114]([O:115][C@H:60]5[C@H:61]([OH:133])[C@@H:62]([OH:132])[C@@H:63]([O:65][C@H:66]6[C@H:71]([OH:72])[C@@H:70]([OH:73])[C@@H:69]([O:74][C@H:75]7[C@H:80]([OH:81])[C@@H:79]([OH:82])[C@@H:78]([O:83][C@H:84]8[C@H:89]([OH:90])[C@@H:88]([OH:91])[C@@H:87]([O:92][C@H:93]1[C@H:98]([OH:99])[C@H:97]2[OH:100])[O:86][C@@H:85]8[CH2:126][OH:127])[O:77][C@@H:76]7[CH2:128][OH:129])[O:68][C@@H:67]6[CH2:130][OH:131])[O:64][C@@H:59]5[CH2:58][OH:134])[O:113][C@@H:112]4[CH2:120][OH:121])[O:104][C@@H:103]3[CH2:122][OH:123]

Participants

4

Reactant 2

HCID 444041beta-CyclodextrinHCID 6436173Rifaximin

Product 1

HCID 131732184HCID 131732184, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7 g of rifaximin was dissolved in 100 ml of ethanol at 30-35° C. To this solution 1.75 g of β-cyclodextrin was added and stirred. The reaction mass was stirred, concentrated to dryness under vacuum at 30-35° C. and then dried completely at 30-35° C. for 24-30 hours to get 8.1 g rifaximin-β cyclodextrin complex.

Workup

  1. stirringThe reaction mass was stirred
  2. concentrationconcentrated to dryness under vacuum at 30-35° C.
  3. customdried completely at 30-35° C. for 24-30 hours
  4. customto get 8.1 g rifaximin-β cyclodextrin complex

Sources & evidence

ORD record
ord-c0837f48529046d4b3524a2f9d25d3f6
Source dataset
uspto-grants-2014_12
Patent number
US08916193B2

Reaction notes

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