HCID 67959439, compound → HCID 67958988, compound

HRID 1404959Notes

Reaction equation

HRID 1404959 reaction equation
[CH3:1][C:2]([C:4]1[C:13]2[O:12][CH2:11][CH2:10][N:9]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:8][C:7]=2[S:6][CH:5]=1)=[CH2:3]>[Pd].CCO>[CH3:3][CH:2]([C:4]1[C:13]2[O:12][CH2:11][CH2:10][N:9]([C:14]([O:16][C:17]([CH3:19])([CH3:18])[CH3:20])=[O:15])[CH2:8][C:7]=2[S:6][CH:5]=1)[CH3:1]

Participants

4

Reactant 1

HCID 67959439HCID 67959439, compound

Product 1

HCID 67958988HCID 67958988, compoundYield 99.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of tert-butyl 8-(1-methylethenyl)-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate (270 mg), 10% palladium on carbon (50 mg) and EtOH (5 mL) was stirred for 12 hr under a hydrogen atmosphere. The insoluble material was filtered off, and the filtrate was concentrated to give the title compound (270 mg, 99.6%) as an oil.

Workup

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-6d592d06448d462aa3ff9e24be2e9321
Source dataset
uspto-grants-2014_12
Patent number
US08916549B2

Reaction notes

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