HCID 67959218, compound → HCID 67959171, compound

HRID 1404998Notes

Reaction equation

HRID 1404998 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]([C:5]1[C:14]2[O:13][CH2:12][CH2:11][N:10]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:9][C:8]=2[S:7][CH:6]=1)=[CH2:4]>[Pd].C(O)C>[F:23][C:2]([F:1])([F:22])[CH:3]([C:5]1[C:14]2[O:13][CH2:12][CH2:11][N:10]([C:15]([O:17][C:18]([CH3:20])([CH3:19])[CH3:21])=[O:16])[CH2:9][C:8]=2[S:7][CH:6]=1)[CH3:4]

Participants

4

Reactant 1

HCID 67959218HCID 67959218, compound

Product 1

HCID 67959171HCID 67959171, compoundYield 99.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of tert-butyl 8-[1-(trifluoromethyl)vinyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate (140 mg), 10% palladium on carbon (50 mg) and ethanol (10 ml) was stirred for 12 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (140 mg, 99.3%) as an oil.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d955f297ff1c4493952545a6bf08dd92
Source dataset
uspto-grants-2014_12
Patent number
US08916549B2

Reaction notes

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