Hydrogen chloride-ethyl acetate → HCID 50925298, compound

HRID 1404999Notes

Reaction equation

HRID 1404999 reaction equation
[F:1][C:2]([F:23])([F:22])[CH:3]([C:5]1[C:14]2[O:13][CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][C:8]=2[S:7][CH:6]=1)[CH3:4].C(OCC)(=O)C.Cl>C(OCC)(=O)C>[F:23][C:2]([F:1])([F:22])[CH:3]([C:5]1[C:14]2[O:13][CH2:12][CH2:11][NH:10][CH2:9][C:8]=2[S:7][CH:6]=1)[CH3:4]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 67959171HCID 67959171, compound

Product 1

HCID 50925298HCID 50925298, compoundYield 88.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl 8-(2,2,2-trifluoro-1-methylethyl)-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate (140 mg) was dissolved in ethyl acetate (2 mL), 4 N hydrogen chloride-ethyl acetate solution (2 mL) was added, and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and the residue was recrystallized from a mixed solvent of methanol and ether to give the title compound (88.4 mg, 76.9%) as a solid.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-5b12641072a94ffe8b5b31611c810802
Source dataset
uspto-grants-2014_12
Patent number
US08916549B2

Reaction notes

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