HCID 86668495, compound → HCID 50925299, compound

HRID 1405000Notes

Reaction equation

HRID 1405000 reaction equation
[CH3:1][C@H:2]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][C:5]2[S:16][CH:17]=[C:18]([CH:19]([CH3:24])[C:20]([F:23])([F:22])[F:21])[C:4]=2[O:3]1>C(OCC)(=O)C.Cl>[CH3:1][C@H:2]1[CH2:8][NH:7][CH2:6][C:5]2[S:16][CH:17]=[C:18]([CH:19]([CH3:24])[C:20]([F:23])([F:21])[F:22])[C:4]=2[O:3]1

Participants

3

Reactant 1

HCID 86668495HCID 86668495, compound

Product 1

HCID 50925299HCID 50925299, compoundYield 105.8%

Reagents, catalysts & solvents 1

HCID 21866389Hydrogen chloride-ethyl acetateSolvent

Procedure

tert-Butyl (2S)-2-methyl-8-(2,2,2-trifluoro-1-methylethyl)-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate (475 mg) was stirred in 4 N hydrogen chloride-ethyl acetate solution (10 mL) for 15 min. The reaction solution was concentrated, and the residue was recrystallized from diethyl ether to give the title compound (365 mg, 93%) as colorless crystals.

Workup

  1. concentrationThe reaction solution was concentrated
  2. customthe residue was recrystallized from diethyl ether

Sources & evidence

ORD record
ord-3f460efab6b34033b86f9b00fe8e2cf6
Source dataset
uspto-grants-2014_12
Patent number
US08916549B2

Reaction notes

Loading…