2-Amino-4-chloro-6-methylpyrimidine → 4-Chloro-5-iodo-6-methylpyrimidin-2-amine

HRID 1405001Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.C1C(=O)N([I:17])C(=O)C1>>[Cl:8][C:6]1[C:5]([I:17])=[C:4]([CH3:9])[N:3]=[C:2]([NH2:1])[N:7]=1

Participants

Reactant 2

HCID 218102-Amino-4-chloro-6-methylpyrimidine

HCID 120273N-Iodosuccinimide

Product 1

HCID 116447204-Chloro-5-iodo-6-methylpyrimidin-2-amine

Procedure

The title compound is synthesized according to general procedure GP1 starting from 10 g (70 mmol) 2-amino-4-chloro-6-methylpyrimidine and 16 g NIS (70 mmol). Yield: 18 g (95%). The crude product is used in next steps without further purification.

Workup

customThe crude product is used in next steps without further purification

Sources & evidence

ORD record: ord-3dc7a0dda7384c8d9bca4e0f58553dd3
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08916548B2

Reaction notes

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