HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-chloro-6-methylpyrimidine → 4-Chloro-5-iodo-6-methylpyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-chloro-6-methylpyrimidine | HCID 21810 | — |
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Product | 4-Chloro-5-iodo-6-methylpyrimidin-2-amine | HCID 11644720 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP1 starting from 10 g (70 mmol) 2-amino-4-chloro-6-methylpyrimidine and 16 g NIS (70 mmol). Yield: 18 g (95%). The crude product is used in next steps without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916548B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-3dc7a0dda7384c8d9bca4e0f58553dd3 |
| Source note | uspto-grants-2014_12 |