2-Amino-4-chloro-6-methylpyrimidine → HCID 21846321, compound

HRID 1405010Notes

Reaction equation

HRID 1405010 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[F:10][C:11]([F:22])([F:21])[C:12]1[CH:13]=[C:14](B(O)O)[CH:15]=[CH:16][CH:17]=1>>[CH3:9][C:4]1[CH:5]=[C:6]([C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([C:11]([F:22])([F:21])[F:10])[CH:17]=2)[N:7]=[C:2]([NH2:1])[N:3]=1

Participants

3

Reactant 2

HCID 218102-Amino-4-chloro-6-methylpyrimidineHCID 27343883-(Trifluoromethyl)phenylboronic acid

Product 1

HCID 21846321HCID 21846321, compound

Procedure

The title compound is synthesized according to general procedure GP4 starting from 2.0 g (14 mmol) 2-amino-4-chloro-6-methylpyrimidine and 3.4 g (18 mmol) 3-trifluoromethyl-phenyl boronic acid. Yield after extraction: 5.0 g (99%).

Workup

  1. customYield
  2. extractionafter extraction

Sources & evidence

ORD record
ord-542f247e211f4c43b68f887a50e87e3b
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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