2-Amino-4-chloro-6-methylpyrimidine → 3-(2-Amino-6-methylpyrimidin-4-yl)benzonitrile

HRID 1405011Notes

Reaction equation

HRID 1405011 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[C:10]([C:12]1[CH:13]=[C:14](B(O)O)[CH:15]=[CH:16][CH:17]=1)#[N:11]>>[CH3:9][C:4]1[CH:5]=[C:6]([C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([C:10]#[N:11])[CH:17]=2)[N:7]=[C:2]([NH2:1])[N:3]=1

Participants

3

Reactant 2

HCID 218102-Amino-4-chloro-6-methylpyrimidineHCID 27343253-Cyanophenylboronic acid

Product 1

HCID 534250313-(2-Amino-6-methylpyrimidin-4-yl)benzonitrile

Procedure

The title compound is synthesized according to general procedure GP4 starting from 2.0 g (14 mmol) 2-amino-4-chloro-6-methylpyrimidine and 2.7 g (18 mmol) 3-cyano-phenyl boronic acid. Yield after extraction and crystallization from diethylether: 3.2 g (100%).

Workup

  1. customYield
  2. extractionafter extraction and crystallization from diethylether

Sources & evidence

ORD record
ord-d9f428ee548542b9a2650a610d874edb
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

Loading…