HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-chloro-6-methylpyrimidine → 3-(2-Amino-6-methylpyrimidin-4-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-chloro-6-methylpyrimidine | HCID 21810 | — |
| Reactant | 3-Cyanophenylboronic acid | HCID 2734325 | — |
| Product | 3-(2-Amino-6-methylpyrimidin-4-yl)benzonitrile | HCID 53425031 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP4 starting from 2.0 g (14 mmol) 2-amino-4-chloro-6-methylpyrimidine and 2.7 g (18 mmol) 3-cyano-phenyl boronic acid. Yield after extraction and crystallization from diethylether: 3.2 g (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916548B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-d9f428ee548542b9a2650a610d874edb |
| Source note | uspto-grants-2014_12 |