Diethyl Ether → HCID 55080241, compound

HRID 1405014Notes

Reaction equation

HRID 1405014 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[S:10](=[C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH2:14]1)(=[O:12])=[O:11].[CH2:22](OCC)C>>[CH3:9][C:4]1[CH:5]=[C:6]([C:16]2[CH:17]=[CH:18][C:13]([S:10]([CH3:22])(=[O:12])=[O:11])=[CH:14][CH:15]=2)[N:7]=[C:2]([NH2:1])[N:3]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 218102-Amino-4-chloro-6-methylpyrimidineHCID 86659252HCID 86659252, compound

Product 1

HCID 55080241HCID 55080241, compound

Procedure

The title compound is synthesized according to general procedure GP4 (A) starting from 1.5 g (10 mmol) 2-amino-4-chloro-6-methylpyrimidine and 2.7 g (14 mmol) 4-sulfonyl-phenyl boronic acid. After treatment of the precipitated product with diethyl ether 2.3 g (75%) of the desired product are obtained.

Workup

  1. customThe title compound is synthesized

Sources & evidence

ORD record
ord-c0ae01f4fb8a43138e5f51c3fae28570
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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