N-Iodosuccinimide → HCID 58513548, compound

HRID 1405016Notes

Reaction equation

HRID 1405016 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]#[N:15])[CH:9]=2)[N:5]=[C:4]([NH2:16])[N:3]=1.C1C(=O)N([I:24])C(=O)C1>C(Cl)Cl.CO>[I:24][C:7]1[C:2]([CH3:1])=[N:3][C:4]([NH2:16])=[N:5][C:6]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]#[N:15])[CH:9]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 534250313-(2-Amino-6-methylpyrimidin-4-yl)benzonitrile

Product 1

HCID 58513548HCID 58513548, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is synthesized according to general procedure GP1 starting from 3.2 g (12 mmol) 4-methyl-6-(3-cyano-phenyl)-pyrimidin-2-ylamine and 2.8 g (13 mmol) NIS. Yield after chromatography on silica gel with DCM/MeOH: 3.5 g (78%).

Sources & evidence

ORD record
ord-cd5a1ee86ab1452d85e3b5de959ef50c
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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