N-Iodosuccinimide → HCID 58513139, compound

HRID 1405017Notes

Reaction equation

HRID 1405017 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[CH:9]=2)[N:5]=[C:4]([NH2:16])[N:3]=1.C1C(=O)N([I:24])C(=O)C1>C(Cl)Cl.CO>[I:24][C:7]1[C:2]([CH3:1])=[N:3][C:4]([NH2:16])=[N:5][C:6]=1[C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[CH:9]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 58513173HCID 58513173, compound

Product 1

HCID 58513139HCID 58513139, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is synthesized according to general procedure GP1 starting from 3.2 g (11 mmol) 4-methyl-6-(3,5-dimethyl-phenyl)-pyrimidin-2-ylamine and 2.5 g (11 mmol) NIS. Yield after chromatography on silica gel with DCM/MeOH: 1.1 g (31%).

Sources & evidence

ORD record
ord-2eb95cfa888e4076b96917b5a3c5c698
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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