Potassium Carbonate → HCID 58513330, compound

HRID 1405023Notes

Reaction equation

HRID 1405023 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]([C:9]2[C:14]([C:15]#[C:16][Si](C)(C)C)=[C:13]([CH3:21])[N:12]=[C:11]([NH2:22])[N:10]=2)[CH:6]=[CH:7][CH:8]=1.C(=O)([O-])[O-].[K+].[K+]>CO.C(Cl)Cl>[C:15]([C:14]1[C:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:23])([F:24])[F:1])[CH:4]=2)=[N:10][C:11]([NH2:22])=[N:12][C:13]=1[CH3:21])#[CH:16]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 58513279HCID 58513279, compound

Product 1

HCID 58513330HCID 58513330, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

The title compound is synthesized according to general procedure GP3 starting from 1.2 g (3.5 mmol) 4-(3-trifluoromethyl-phenyl)-6-methyl-5-trimethylsilanylethynyl-pyrimidin-2-ylamine (A-36) and 120 mg (0.87 mmol) potassium carbonate in 5 mL MeOH. After stirring for 2 h at RT, the reaction mixture is diluted with DCM and the organic phase is extracted with water. The organic phase is dried over NGP2SO4 and the solvent is removed in vacuo. Yield: 523 mg (54%).

Workup

  1. extractionthe organic phase is extracted with water
  2. customThe organic phase is dried over NGP2SO4
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-fad66ebbde644a8a99cb0bf866d26f9f
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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