N-Iodosuccinimide → HCID 58513500, compound

HRID 1405035Notes

Reaction equation

HRID 1405035 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:9]2[N:14]=[C:13]([NH2:15])[N:12]=[C:11]([NH2:16])[CH:10]=2)[CH:6]=[CH:7][CH:8]=1.C1C(=O)N([I:26])C(=O)C1>>[I:26][C:10]1[C:11]([NH2:16])=[N:12][C:13]([NH2:15])=[N:14][C:9]=1[C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:17])[F:18])[CH:4]=1

Participants

3

Reactant 2

HCID 120273N-IodosuccinimideHCID 58513167HCID 58513167, compound

Product 1

HCID 58513500HCID 58513500, compound

Procedure

The title compound is synthesized according to general procedure GP1 starting from 1.8 g (7.1 mmol) 6-(3-trifluoromethyl-phenyl)-pyrimidine-2,4-diamine and 1.8 g (7.8 mmol) NIS. Yield: 2.0 g (74%).

Sources & evidence

ORD record
ord-ce4d9b5f5e9a4e2b8691721b196a9b3f
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

Loading…