HCID 58513394, compound → HCID 58513485, compound

HRID 1405043Notes

Reaction equation

HRID 1405043 reaction equation
C[O:2][C:3](=[O:28])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:15]([C:16]#[C:17][C:18]3[CH:19]=[N:20][C:21]([NH2:24])=[CH:22][CH:23]=3)=[C:14]([CH2:25][CH3:26])[N:13]=[C:12]([NH2:27])[N:11]=2)=[CH:6][CH:5]=1>C1COCC1>[NH2:27][C:12]1[N:11]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([C:3]([OH:28])=[O:2])=[CH:9][CH:8]=2)[C:15]([C:16]#[C:17][C:18]2[CH:19]=[N:20][C:21]([NH2:24])=[CH:22][CH:23]=2)=[C:14]([CH2:25][CH3:26])[N:13]=1

Participants

3

Reactant 1

HCID 58513394HCID 58513394, compound

Product 1

HCID 58513485HCID 58513485, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is synthesized according to general procedure GP8 starting from 120 mg (0.32 mmol) 4-[2-amino-5-(6-amino-pyridin-3-ylethynyl)-6-ethyl-pyrimidin-4-yl]-benzoic acid methyl ester using 0.48 mL (0.48 mmol) 1 N NaOH in 3 mL THF.

Sources & evidence

ORD record
ord-7c79b088768d46839239ab602d451fca
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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