HCID 67004195, compound → HCID 67004264, compound

HRID 1405046Notes

Reaction equation

HRID 1405046 reaction equation
C[O:2][C:3](=[O:29])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:15]([C:16]#[C:17][C:18]3[CH:19]=[N:20][C:21]([NH:24][CH3:25])=[CH:22][CH:23]=3)=[C:14]([CH3:26])[N:13]=[C:12]([NH2:27])[N:11]=2)=[CH:6][C:5]=1[Cl:28]>C1COCC1>[NH2:27][C:12]1[N:11]=[C:10]([C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:29])=[O:2])=[C:5]([Cl:28])[CH:6]=2)[C:15]([C:16]#[C:17][C:18]2[CH:19]=[N:20][C:21]([NH:24][CH3:25])=[CH:22][CH:23]=2)=[C:14]([CH3:26])[N:13]=1

Participants

3

Reactant 1

HCID 67004195HCID 67004195, compound

Product 1

HCID 67004264HCID 67004264, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is synthesized according to general procedure GP8 starting from 700 mg (1.7 mmol) 4-[2-amino-6-methyl-5-(6-methylamino-pyridin-3-ylethynyl)-pyrimidin-4-yl]-2-chloro-benzoic acid methyl ester using 2.6 mL (2.6 mmol) 1 N NaOH in 10 mL THF. The product precipitates and is isolated by filtration. The product is washed with water and used without further purification. Yield: 370 mg (55%).

Workup

  1. customThe product precipitates
  2. customis isolated by filtration
  3. washThe product is washed with water
  4. customused without further purification

Sources & evidence

ORD record
ord-c9ce5146d0da43cba228f7367dbbf4ae
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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