HCID 58513426, compound → HCID 58513471, compound

HRID 1405047Notes

Reaction equation

HRID 1405047 reaction equation
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:15]([C:16]#[C:17][C:18]3[CH:19]=[N:20][C:21]([NH2:24])=[CH:22][CH:23]=3)=[C:14]([CH3:25])[N:13]=[C:12]([NH2:26])[N:11]=2)=[CH:6][CH:5]=1>C1COCC1>[NH2:26][C:12]1[N:11]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([C:3]([OH:27])=[O:2])=[CH:9][CH:8]=2)[C:15]([C:16]#[C:17][C:18]2[CH:19]=[N:20][C:21]([NH2:24])=[CH:22][CH:23]=2)=[C:14]([CH3:25])[N:13]=1

Participants

3

Reactant 1

HCID 58513426HCID 58513426, compound

Product 1

HCID 58513471HCID 58513471, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is synthesized according to general procedure GP8 starting from 2.3 g (6.4 mmol) 4-[2-amino-5-(6-amino-pyridin-3-ylethynyl)-6-methyl-pyrimidin-4-yl]-benzoic acid methyl ester using 9.6 mL (9.6 mmol) 1 N NaOH in 20 mL THF. The product precipitates and is isolated by filtration and is washed with water. Yield: 2.2 g (99%).

Workup

  1. customThe product precipitates
  2. customis isolated by filtration
  3. washis washed with water

Sources & evidence

ORD record
ord-b00dc41239474768a44bb999acedbbbd
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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