1-Bromo-2-chloro-4-nitrobenzene → 3-(2-Chloro-4-nitrophenyl)-4-methylpyridine

HRID 1405077Notes

Reaction equation

HRID 1405077 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1B(O)O.Br[C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:13]=1[Cl:21].CC1C=CN=CC=1C1C=CC=C2C=1C=NN2>>[Cl:21][C:13]1[CH:14]=[C:15]([N+:18]([O-:20])=[O:19])[CH:16]=[CH:17][C:12]=1[C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:2]=1[CH3:1]

Participants

4

Reactant 3

HCID 346671-Bromo-2-chloro-4-nitrobenzeneHCID 27627114-Methylpyridine-3-Boronic AcidHCID 667156544-(4-methylpyridin-3-yl)-1H-indazole

Product 1

HCID 667148853-(2-Chloro-4-nitrophenyl)-4-methylpyridine

Procedure

Intermediate 27A was prepared from Intermediate 1A and 1-bromo-2-chloro-4-nitrobenzene by the procedure described for the preparation of Intermediate 1C. HPLC Ret timej:1.30 min. MS (ES): m/z=249.0 [M+H]+.

Workup

  1. custom1.30 min

Sources & evidence

ORD record
ord-6518bae7122f403b901af7aab073f2e3
Source dataset
uspto-grants-2014_12
Patent number
US08916553B2

Reaction notes

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