HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Benzyloxy-4-fluorophenylboronic acid → 4-[2-(Benzyloxy)-4-fluorophenyl]-N-{3-[(methylsulfonyl)methyl]phenyl)-1,3,5-triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Benzyloxy-4-fluorophenylboronic acid | HCID 2782665 | — |
| Reactant | 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine | HCID 21956343 | — |
| Product | 4-[2-(Benzyloxy)-4-fluorophenyl]-N-{3-[(methylsulfonyl)methyl]phenyl)-1,3,5-triazin-2-amine | HCID 66571226 | — |
Reaction Steps
Example 4 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and [2-(benzyloxy)-4-fluorophenyl]boronic acid (ABCR GmbH & CO. KG). The batch was purified by preparative HPLC:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916557B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-3d355e1a761e48dcad125d27e4888aac |
| Source note | uspto-grants-2014_12 |