HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-isopropoxyphenylboronic acid → 4-[4-Fluoro-2-(propan-2-yloxy)phenyl]-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-isopropoxyphenylboronic acid | HCID 16217202 | — |
| Reactant | 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine | HCID 21956343 | — |
| Product | 4-[4-Fluoro-2-(propan-2-yloxy)phenyl]-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine | HCID 66576280 | — |
Reaction Steps
Example 5 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and [4-fluoro-2-(propan-2-yloxy)phenyl]boronic acid (Aldrich Chemical Company Inc.). The batch was purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916557B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-902254eeb6ff4bf08534015e5023b9eb |
| Source note | uspto-grants-2014_12 |