反应详情

温度

-15 °C

A solution of sodium methoxyde (15.5 mL, 25 wt % in methanol) was diluted with methanol (85 mL) and treated with 2-propanethiol (6.3 mL) at room temperature for 60 minutes, cooled to −15° C., treated with 3-nitrobenzylchloride (10 g) in 3 portions, kept for 2 hours at −15° C., then the temperature was increased to room temperature. The reaction mixture was concentrated in vacuo, treated with diethyl ether (300 mL), washed with water (2×100 mL) and brine (100 mL), dried with sodium sulfate and evaporated to dryness. The title compound (12.3 g) was thus obtained and used without further purification.

1. temperaturethe temperature was increased to room temperature
2. concentrationThe reaction mixture was concentrated in vacuo
3. additiontreated with diethyl ether (300 mL)
4. washwashed with water (2×100 mL) and brine (100 mL)
5. dry with materialdried with sodium sulfate
6. customevaporated to dryness