1-Butanol → 4-(2-Butoxy-4-fluorophenyl)-N-{3-[(methylsulfonyl)-methyl]phenyl}-1,3,5-triazin-2-amine

HRID 1405215Notes

Reaction equation

HRID 1405215 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[CH2:27]([OH:31])[CH2:28][CH2:29][CH3:30]>>[CH2:27]([O:31][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1)[CH2:28][CH2:29][CH3:30]

Participants

3

Reactant 2

HCID 2631-ButanolHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 665767584-(2-Butoxy-4-fluorophenyl)-N-{3-[(methylsulfonyl)-methyl]phenyl}-1,3,5-triazin-2-amine

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (75 mg; 0.19 mmol), intermediate 42.1, and butan-1-ol (74 μl; 0.773 mmol), example 44 was prepared analogously to the procedure for the preparation of example 42.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 42

Sources & evidence

ORD record
ord-16cd2bbdfc6242c4a7b5f9f51f5a80cd
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

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