(1-Methylcyclopropyl)methanol → 4-{4-Fluoro-2-[(1-methylcyclopropyl)methoxy]phenyl}-N-{3-[(methylsulfonyl)-methyl]-phenyl}-1,3,5-triazin-2-amine

HRID 1405220노트

반응식

HRID 1405220 반응식
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[CH3:27][C:28]1([CH2:31][OH:32])[CH2:30][CH2:29]1>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=3)[N:10]=2)=[C:2]([O:32][CH2:31][C:28]2([CH3:27])[CH2:30][CH2:29]2)[CH:7]=1

참가 물질

3

반응물 2

HCID 137701(1-Methylcyclopropyl)methanolHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

생성물 1

HCID 665768384-{4-Fluoro-2-[(1-methylcyclopropyl)methoxy]phenyl}-N-{3-[(methylsulfonyl)-methyl]-phenyl}-1,3,5-triazin-2-amine

실험 절차

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (75 mg; 0.19 mmol), intermediate 42.1, and 1-methylcyclopropanmethanol (76.3 mg; 0.841 mmol), example 49 was prepared analogously to the procedure for the preparation of example 42.

후처리

  1. customwas prepared analogously to the procedure for the preparation of example 42

출처 및 근거

ORD 기록
ord-b69937e03f0a4bb19d4ed4eccd13da76
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916557B2

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