HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-Methylcyclopropyl)methanol → 4-{4-Fluoro-2-[(1-methylcyclopropyl)methoxy]phenyl}-N-{3-[(methylsulfonyl)-methyl]-phenyl}-1,3,5-triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-Methylcyclopropyl)methanol | HCID 137701 | — |
| Reactant | 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine | HCID 70976524 | — |
| Product | 4-{4-Fluoro-2-[(1-methylcyclopropyl)methoxy]phenyl}-N-{3-[(methylsulfonyl)-methyl]-phenyl}-1,3,5-triazin-2-amine | HCID 66576838 | — |
Reaction Steps
Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (75 mg; 0.19 mmol), intermediate 42.1, and 1-methylcyclopropanmethanol (76.3 mg; 0.841 mmol), example 49 was prepared analogously to the procedure for the preparation of example 42.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916557B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-b69937e03f0a4bb19d4ed4eccd13da76 |
| Source note | uspto-grants-2014_12 |