3-Fluoro-5-(trifluoromethyl)benzyl alcohol → HCID 66575976, compound

HRID 1405247Notes

Reaction equation

HRID 1405247 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[F:27][C:28]1[CH:29]=[C:30]([CH:33]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:35]=1)[CH2:31][OH:32]>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=3)[N:10]=2)=[C:2]([O:32][CH2:31][C:30]2[CH:33]=[C:34]([C:36]([F:37])([F:38])[F:39])[CH:35]=[C:28]([F:27])[CH:29]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 5891763-Fluoro-5-(trifluoromethyl)benzyl alcoholHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 66575976HCID 66575976, compound

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (75 mg; 0.197 mmol), intermediate 42.1, and 3-fluoro-5-(trifluoromethyl)benzyl alcohol (158 mg; 0.789 mmol), example 78 was prepared analogously to the procedure for the preparation of example 42.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 42

Sources & evidence

ORD record
ord-4a2d35b18ece418aaa75c913e6d624e2
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

Loading…