2,5-Difluorobenzyl alcohol → 4-{2-[(2,5-Difluorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(methylsulfonyl)methyl]-phenyl}-1,3,5-triazin-2-amine

HRID 1405250Notes

Reaction equation

HRID 1405250 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[F:27][C:28]1[CH:35]=[CH:34][C:33]([F:36])=[CH:32][C:29]=1[CH2:30][OH:31]>>[F:27][C:28]1[CH:35]=[CH:34][C:33]([F:36])=[CH:32][C:29]=1[CH2:30][O:31][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1

Participants

3

Reactant 2

HCID 5225992,5-Difluorobenzyl alcoholHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 665760534-{2-[(2,5-Difluorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(methylsulfonyl)methyl]-phenyl}-1,3,5-triazin-2-amine

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (70 mg; 0.184 mmol), intermediate 42.1, and 2,5-difluorobenzyl alcohol (107 mg; 0.736 mmol), example 81 was prepared analogously to the procedure for the preparation of example 42.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 42

Sources & evidence

ORD record
ord-f68c16120fa3418388dfd4a5964b1bd8
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

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