HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Difluorobenzyl alcohol → 4-{2-[(2,5-Difluorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(methylsulfonyl)methyl]-phenyl}-1,3,5-triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Difluorobenzyl alcohol | HCID 522599 | — |
| Reactant | 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine | HCID 70976524 | — |
| Product | 4-{2-[(2,5-Difluorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(methylsulfonyl)methyl]-phenyl}-1,3,5-triazin-2-amine | HCID 66576053 | — |
Reaction Steps
Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (70 mg; 0.184 mmol), intermediate 42.1, and 2,5-difluorobenzyl alcohol (107 mg; 0.736 mmol), example 81 was prepared analogously to the procedure for the preparation of example 42.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916557B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-f68c16120fa3418388dfd4a5964b1bd8 |
| Source note | uspto-grants-2014_12 |