反应详情

A solution of methyl 2-[1-[(tert-butoxy)carbonyl]-1H-indazol-5-yl]-3-[methyl(propan-2-yl)amino]quinoxaline-6-carboxylate (624 mg, 1.31 mmol) and trifluoroacetic acid (4 ml) in dichloromethane (20 ml) was stirred for 1 h at room temperature. The resulting solution was added water (200 ml) and adjusted to pH 8, extracted with dichloromethane (5×50 ml), dried over anhydrous magnesium and concentrated in vacuo to afford methyl 2-(1H-indazol-5-yl)-3-[methyl(propan-2-yl)amino]quinoxaline-6-carboxylate as a yellow solid (442 mg, crude).

1. extractionextracted with dichloromethane (5×50 ml)
2. dry with materialdried over anhydrous magnesium
3. concentrationconcentrated in vacuo