Tert-Butylamine → HCID 70654302, compound

HRID 1405317Notes

Reaction equation

HRID 1405317 reaction equation
[CH3:1][N:2]([CH:17]([CH3:19])[CH3:18])[C:3]1[C:4](=[O:16])[NH:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([C:13]([OH:15])=O)=[CH:8][CH:7]=2.[CH3:20][C:21]([NH2:24])([CH3:23])[CH3:22].C(P1(=O)OP(CCC)(=O)OP(CCC)(=O)O1)CC>ClCCl>[C:21]([NH:24][C:13]([C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[NH:5][C:4](=[O:16])[C:3]([N:2]([CH3:1])[CH:17]([CH3:19])[CH3:18])=[N:12]2)=[O:15])([CH3:23])([CH3:22])[CH3:20]

Participants

5

Reactant 3

HCID 6385Tert-ButylamineHCID 111923Propylphosphonic anhydrideHCID 70654212HCID 70654212, compound

Product 1

HCID 70654302HCID 70654302, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-[methyl(propan-2-yl)amino]-2-oxo-1,2-dihydroquinoxaline-6-carboxylic acid (1 g, 3.83 mmol) in dichloromethane (50 ml) was added 2-methylpropan-2-amine (560 mg, 7.66 mmol), TEA (967 mg, 9.56 mmol), and T3P (1.83 g, 7.66 mmol). The resulting solution was stirred overnight at room temperature and then concentrated in vacuo to afford N-tert-butyl-3-[methyl(propan-2-yl)amino]-2-oxo-1,2-dihydroquinoxaline-6-carboxamide as yellow oil (1.5 g, crude).

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b0450d6d02b147408e142f5b12298076
Source dataset
uspto-grants-2014_12
Patent number
US08916561B2

Reaction notes

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