Triethylamine → HCID 70654333, compound

HRID 1405325Notes

Reaction equation

HRID 1405325 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:18]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[N:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH2:27])[CH:15]=3)[N:10]=2)=[CH:5][CH:4]=1.[CH3:28][S:29](Cl)(=[O:31])=[O:30].C(N(CC)CC)C>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:18]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[N:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([N:27]([S:29]([CH3:28])(=[O:31])=[O:30])[S:29]([CH3:28])(=[O:31])=[O:30])[CH:15]=3)[N:10]=2)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 459144HCID 459144, compound

Product 1

HCID 70654333HCID 70654333, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2,3-bis(4-methoxyphenyl)quinoxalin-6-amine (123.2 mg, 0.35 mmol, 1.00 equiv) in dichloromethane (20 mL) was added methanesulfonyl chloride (47.2 mg, 0.41 mmol, 1.20 equiv) and triethylamine (174.3 mg, 1.73 mmol, 5.00 equiv). The resulting solution was stirred for 1.5 h at room temperature. The resulting mixture was concentrated in vacuo, resulting in 179.55 mg (81%) of N-(2,3-bis(4-methoxyphenyl)quinoxalin-6-yl)-N-(methylsulfonyl)methanesulfonamide as a brown solid.

Workup

  1. concentrationThe resulting mixture was concentrated in vacuo
  2. customresulting in 179.55 mg (81%) of N-(2,3-bis(4-methoxyphenyl)quinoxalin-6-yl)-N-(methylsulfonyl)methanesulfonamide as a brown solid

Sources & evidence

ORD record
ord-0897f8ee191d4c859c6a869dc1c6c829
Source dataset
uspto-grants-2014_12
Patent number
US08916561B2

Reaction notes

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