1,2,3,4-Tetrahydroquinoline-8-carboxylic acid → HCID 86723071, compound

HRID 1405633Notes

Reaction equation

HRID 1405633 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[C:11]([OH:13])=O)[CH2:4][CH2:3][CH2:2]1.[NH2:14][CH2:15][CH2:16][CH2:17][C@H:18]1[O:22][C:21](=[O:23])[N:20]([C:24]2[CH:25]=[CH:26][C:27]3[S:32][CH2:31][C:30](=[O:33])[NH:29][C:28]=3[CH:34]=2)[CH2:19]1>>[O:23]=[C:21]1[N:20]([C:24]2[CH:25]=[CH:26][C:27]3[S:32][CH2:31][C:30](=[O:33])[NH:29][C:28]=3[CH:34]=2)[CH2:19][C@@H:18]([CH2:17][CH2:16][CH2:15][NH:14][C:11]([C:9]2[CH:8]=[CH:7][CH:6]=[C:5]3[C:10]=2[NH:1][CH2:2][CH2:3][CH2:4]3)=[O:13])[O:22]1

Participants

3

Reactant 2

HCID 27855891,2,3,4-Tetrahydroquinoline-8-carboxylic acidHCID 673035876-[(R)-5-(3-amino-propyl)-2-oxo-oxazolidin-3-yl]-4H-benzo[1,4]thiazin-3-one

Product 1

HCID 86723071HCID 86723071, compoundYield 85%

Procedure

Starting from 1,2,3,4-tetrahydroquinoline-8-carboxylic acid and 6-[(R)-5-(3-amino-propyl)-2-oxo-oxazolidin-3-yl]-4H-benzo[1,4]thiazin-3-one (described in WO 2010/041219) and using Procedure D, the title compound was obtained as a beige solid (114 mg; 85% yield).

Sources & evidence

ORD record
ord-cda52ab3017341739cf173fc4131c82c
Source dataset
uspto-grants-2014_12
Patent number
US08916573B2

Reaction notes

Loading…