1-Cyclopropyl-6,7-difluoro-8-methoxy-1H-quinazoline-2,4-dione → HCID 71607922, compound

HRID 1405634Notes

Reaction equation

HRID 1405634 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:17])=[C:11]([F:16])[C:12]=3[O:14][CH3:15])[C:7](=[O:18])[NH:6][C:5]2=[O:19])[CH2:3][CH2:2]1.CS(O[CH2:25][CH2:26][CH2:27][C@@H:28]1[O:32][C:31](=[O:33])[N:30]([C:34]2[CH:35]=[CH:36][C:37]3[S:42][CH2:41][C:40](=[O:43])[NH:39][C:38]=3[CH:44]=2)[CH2:29]1)(=O)=O>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:17])=[C:11]([F:16])[C:12]=3[O:14][CH3:15])[C:7](=[O:18])[N:6]([CH2:25][CH2:26][CH2:27][C@@H:28]3[O:32][C:31](=[O:33])[N:30]([C:34]4[CH:35]=[CH:36][C:37]5[S:42][CH2:41][C:40](=[O:43])[NH:39][C:38]=5[CH:44]=4)[CH2:29]3)[C:5]2=[O:19])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 112656421-Cyclopropyl-6,7-difluoro-8-methoxy-1H-quinazoline-2,4-dioneHCID 86723072HCID 86723072, compound

Product 1

HCID 71607922HCID 71607922, compoundYield 65%

Procedure

Starting from 1-cyclopropyl-6,7-difluoro-8-methoxy-1H-quinazoline-2,4-dione (described in Org. Process Res. Dev. (2007), 11(3), 441-449) and 6-[(5S)-5-[3-[(methylsulfonyl)oxy]propyl]-2-oxo-3-oxazolidinyl]-2H-1,4-benzothiazin-3(4H)-one (prepared according to WO 2010/041194) and using Procedure E, the title compound was obtained as a colourless solid (140 mg; 65% yield).

Sources & evidence

ORD record
ord-a3ca26a20ba04dbfbbb703d8c3850e36
Source dataset
uspto-grants-2014_12
Patent number
US08916573B2

Reaction notes

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