HRID1405634

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1c(F)c(F)cc2c(=O)[nH]c(=O)n(C3CC3)c12

HCID11265642

1-Cyclopropyl-6,7-difluoro-8-methoxy-1H-quinazoline-2,4-dione

C12H10F2N2O3

结构：CS(=O)(=O)OCCC[C@H]1CN(c2ccc3c(c2)NC(=O)CS3)C(=O)O1

HCID86723072

未命名化合物

PRODUCTS

生成物

结构：COc1c(F)c(F)cc2c(=O)n(CCC[C@H]3CN(c4ccc5c(c4)NC(=O)CS5)C(=O)O3)c(=O)n(C3CC3)c12

HCID71607922

未命名化合物

收率 65%

PROCEDURE

实验过程

Starting from 1-cyclopropyl-6,7-difluoro-8-methoxy-1H-quinazoline-2,4-dione (described in Org. Process Res. Dev. (2007), 11(3), 441-449) and 6-[(5S)-5-[3-[(methylsulfonyl)oxy]propyl]-2-oxo-3-oxazolidinyl]-2H-1,4-benzothiazin-3(4H)-one (prepared according to WO 2010/041194) and using Procedure E, the title compound was obtained as a colourless solid (140 mg; 65% yield).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a3ca26a20ba04dbfbbb703d8c3850e36
来源数据集: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08916573B2
来源说明: uspto-grants-2014_12

反应 SMILES

[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:17])=[C:11]([F:16])[C:12]=3[O:14][CH3:15])[C:7](=[O:18])[NH:6][C:5]2=[O:19])[CH2:3][CH2:2]1.CS(O[CH2:25][CH2:26][CH2:27][C@@H:28]1[O:32][C:31](=[O:33])[N:30]([C:34]2[CH:35]=[CH:36][C:37]3[S:42][CH2:41][C:40](=[O:43])[NH:39][C:38]=3[CH:44]=2)[CH2:29]1)(=O)=O>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:17])=[C:11]([F:16])[C:12]=3[O:14][CH3:15])[C:7](=[O:18])[N:6]([CH2:25][CH2:26][CH2:27][C@@H:28]3[O:32][C:31](=[O:33])[N:30]([C:34]4[CH:35]=[CH:36][C:37]5[S:42][CH2:41][C:40](=[O:43])[NH:39][C:38]=5[CH:44]=4)[CH2:29]3)[C:5]2=[O:19])[CH2:2][CH2:3]1