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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1405634Generated: November 3, 2026

1-Cyclopropyl-6,7-difluoro-8-methoxy-1H-quinazoline-2,4-dione → HCID 71607922, compound

https://huagongshe.com/reaction/1405634

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclopropyl-6,7-difluoro-8-methoxy-1H-quinazoline-2,4-dioneHCID 11265642—
ReactantHCID 86723072HCID 86723072—
ProductHCID 71607922HCID 7160792265%

Reaction Steps

Starting from 1-cyclopropyl-6,7-difluoro-8-methoxy-1H-quinazoline-2,4-dione (described in Org. Process Res. Dev. (2007), 11(3), 441-449) and 6-[(5S)-5-[3-[(methylsulfonyl)oxy]propyl]-2-oxo-3-oxazolidinyl]-2H-1,4-benzothiazin-3(4H)-one (prepared according to WO 2010/041194) and using Procedure E, the title compound was obtained as a colourless solid (140 mg; 65% yield).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08916573B2
Source datasetuspto-grants-2014_12
ORD IDord-a3ca26a20ba04dbfbbb703d8c3850e36
Source noteuspto-grants-2014_12