HCID 66747904, compound → HCID 66748509, compound

HRID 1405683Notes

Reaction equation

HRID 1405683 reaction equation
[F:1][C:2]([F:23])([F:22])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:15]3=[N:16][S:17](=[O:21])(=[O:20])[CH2:18][CH2:19][N:14]3[CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1>C1COCC1.C(O)C.[C].[Rh]>[F:23][C:2]([F:1])([F:22])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[C:15]3=[N:16][S:17](=[O:21])(=[O:20])[CH2:18][CH2:19][N:14]3[CH2:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1

Participants

5

Reactant 1

HCID 66747904HCID 66747904, compound

Product 1

HCID 66748509HCID 66748509, compoundYield 100.8%

Reagents, catalysts & solvents 3

HCID 178503043HCID 178503043, compoundCatalystHCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 5% rhodium-carbon (50% wet, 15 mg) and 9-[4-(trifluoromethoxy)phenyl]-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (150 mg) in THF (30 mL) and ethanol (30 mL) was stirred under a hydrogen atmosphere at room temperature for 7 hr. The reaction mixture was filtered, the filtrate was concentrated to give the title compound (153 mg) as a gray white solid. The obtained solid was crystallized from THF and diisopropyl ether to give a gray white solid.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-a74d078604064ca4aa823db3d0ca86bb
Source dataset
uspto-grants-2014_12
Patent number
US08916551B2

Reaction notes

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