HCID 66747989, compound → HCID 66748707, compound

HRID 1405692Notes

Reaction equation

HRID 1405692 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]1[C:16]2=[N:17][S:18](=[O:22])(=[O:21])[CH2:19][CH2:20][N:15]2[CH:14]=[CH:13][CH:12]=1>C1COCC1.CO.[Pt](=O)=O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]1[C:16]2=[N:17][S:18](=[O:21])(=[O:22])[CH2:19][CH2:20][N:15]2[CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 66747989HCID 66747989, compound

Product 1

HCID 66748707HCID 66748707, compoundYield 68.9%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

To a solution of 9-naphthalen-2-yl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (150 mg) in THF/methanol (30 mL/30 mL) was added platinum (IV) oxide (50 mg). The reaction mixture was stirred under a hydrogen atmosphere at room temperature for 7 hr, and insoluble material was filtered off through celite. The filtrate was concentrated under reduced pressure, and the obtained residue was purified by recrystallization (methanol-THF/diisopropyl ether) to give the title compound (104.7 mg).

Workup

  1. filtrationinsoluble material was filtered off through celite
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customthe obtained residue was purified by recrystallization (methanol-THF/diisopropyl ether)

Sources & evidence

ORD record
ord-c3bc59ff8eee4cd7af59652067ad017b
Source dataset
uspto-grants-2014_12
Patent number
US08916551B2

Reaction notes

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