HCID 66748164, compound → HCID 66823919, compound

HRID 1405865Notes

Reaction equation

HRID 1405865 reaction equation
[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:16]3=[N:17][S:18](=[O:22])(=[O:21])[CH2:19][CH2:20][N:15]3[CH:14]=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)[CH2:2][CH3:3]>CO.[Pt](=O)=O>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[C:16]3=[N:17][S:18](=[O:21])(=[O:22])[CH2:19][CH2:20][N:15]3[CH2:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1)[CH2:2][CH3:3]

Participants

4

Reactant 1

HCID 66748164HCID 66748164, compound

Product 1

HCID 66823919HCID 66823919, compoundYield 37.5%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

A mixture of 9-(4-propoxyphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (300 mg) and platinum(IV) oxide (32.1 mg) in MeOH (10 mL) was stirred at room temperature under H2 for 20 hr. The reaction mixture was filtered by Celite and the filtrate was concentrated in vacuo. The residue was recrystallized from EtOAc-MeOH to give the title compound (114 mg) as a white solid.

Workup

  1. filtrationThe reaction mixture was filtered by Celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe residue was recrystallized from EtOAc-MeOH

Sources & evidence

ORD record
ord-6688749a890c40208e21b7853dab5192
Source dataset
uspto-grants-2014_12
Patent number
US08916551B2

Reaction notes

Loading…