反应详情

A mixture of 3-chlorophenylboronic acid (167 mg), 4-(2,2-dioxido-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazin-9-yl)phenol (100 mg), diacetoxycopper (130 mg), triethylamine (0.248 mL), and powdered 4A MS (1.00 g) in MeCN (10 mL) was stirred at room temperature overnight. The mixture was added with NH silica gel, concentrated in vacuo, and purified by column chromatography (NH silica gel, eluted with MeOH in EtOAc), and then recrystallized from EtOAc—IPE to give the title compound (37.0 mg) as a white solid.

1. additionThe mixture was added with NH silica gel
2. concentrationconcentrated in vacuo
3. custompurified by column chromatography (NH silica gel, eluted with MeOH in EtOAc)
4. customrecrystallized from EtOAc—IPE