Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Potassium Acetate | HCID 517044 | — |
| Reactant | 4-Methoxy-3-(2-methoxy-ethoxy)-benzaldehyde | HCID 6484657 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 86701187 | HCID 86701187 | 89.3% |
Reaction Steps
To a solution of 4-methoxy-3-(2-methoxyethoxy)benzaldehyde (10 g) in AcOH (80 mL) was added KOAc (9.5 g) and NH2OH.HCl (6.7 g). The resulting mixture was heated at 130° C. for 18 h under N2 atmospheres. After reaction finished, the mixture was poured into water (400 mL). The solid was collected, washed with water (100 mL) and air-dried to give 4-methoxy-3-(2-methoxyethoxy)benzonitrile (8.8 g) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08916572B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-26056771493d4a13b91c85ad9368143f |
|---|
| Source note | uspto-grants-2014_12 |
|---|
