反应详情

Chloromethyl chloroformate (1.96 g, 15.2 mmol) and cholesterol (5.0 g, 12.9 mmol) was dissolved in CH2Cl2 (10 ml). The solution was cooled. Pyridine (1.21 g, 15.3 mmol) was dripped into the stirred solution over 5 minutes. Heat was produced and the reaction gave a clear solution from a somewhat unclear starting solution. After 24 hours at room temperature, the mixture was diluted with CH2Cl2 (50 ml), washed with 0.5M HCl (50 ml) and water (3×25 ml). After treatment with MgSO4, the solution was evaporated to dryness.

1. temperatureThe solution was cooled
2. temperatureHeat
3. customwas produced
4. customthe reaction gave a clear solution from
5. washwashed with 0.5M HCl (50 ml) and water (3×25 ml)
6. customAfter treatment with MgSO4, the solution was evaporated to dryness