Hydrochloric Acid → HCID 178524939, compound

Participants

Reaction Steps

Ethyl 8-oxo-1,4,5,6,7,8-hexahydrocyclohepta[c]pyrazole-3-carboxylate (2.67 g, 12.01 mmol) was suspended in EtOH (80 mL) and treated with a 2 M solution of NaOH (24 mL, 48.0 mmol) at reflux temperature for 1 h. After cooling the mixture is neutralized with 2 N HCl (24 mL) and the resulting precipitate was collected by filtration to give 2.0 g of the title compound (90% yield) as a white solid.

Provenance & Evidence