Hydrochloric Acid → HCID 178524939, compound

HRID 1406002Notes

Reaction equation

HRID 1406002 reaction equation
[O:1]=[C:2]1[C:8]2[NH:9][N:10]=[C:11]([C:12]([O:14]CC)=[O:13])[C:7]=2[CH2:6][CH2:5][CH2:4][CH2:3]1.[OH-].[Na+].Cl>CCO>[O:1]=[C:2]1[C:8]2[NH:9][N:10]=[C:11]([C:12]([OH:14])=[O:13])[C:7]=2[CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178470480HCID 178470480, compound

Product 1

HCID 178524939HCID 178524939, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 8-oxo-1,4,5,6,7,8-hexahydrocyclohepta[c]pyrazole-3-carboxylate (2.67 g, 12.01 mmol) was suspended in EtOH (80 mL) and treated with a 2 M solution of NaOH (24 mL, 48.0 mmol) at reflux temperature for 1 h. After cooling the mixture is neutralized with 2 N HCl (24 mL) and the resulting precipitate was collected by filtration to give 2.0 g of the title compound (90% yield) as a white solid.

Workup

  1. temperatureat reflux temperature for 1 h
  2. temperatureAfter cooling the mixture
  3. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-8ecc126dfd524206bf87f97bed7873c3
Source dataset
uspto-grants-2014_12
Patent number
US08916577B2

Reaction notes

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