反应详情

To a solution of ethyl (3,3-dimethoxy-2-oxocycloheptyl)(oxo)acetate (0.850 g, 3.12 mmol) in 15 mL of EtOH, hydroxylamine hydrochloride (0.225 g, 3.24 mmol) was added. The mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure and the crude solid was purified by flash chromatography on silica gel (eluant: AcOEt/hexane:1/9) to afford 0.245 g (35% yield) of:

1. customThe solvent was removed under reduced pressure
2. customthe crude solid was purified by flash chromatography on silica gel (eluant: AcOEt/hexane:1/9)
3. customto afford 0.245 g (35% yield) of: