Hydroxyamine hydrochloride → HCID 68294859, compound

HRID 1406008Notes

Reaction equation

HRID 1406008 reaction equation
C[O:2][C:3]1(OC)[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]([C:10](=[O:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:4]1=O.Cl.[NH2:21]O>CCO>[O:2]=[C:3]1[C:4]2=[N:21][O:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 68358222HCID 68358222, compound

Product 1

HCID 68294859HCID 68294859, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl (3,3-dimethoxy-2-oxocycloheptyl)(oxo)acetate (0.850 g, 3.12 mmol) in 15 mL of EtOH, hydroxylamine hydrochloride (0.225 g, 3.24 mmol) was added. The mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure and the crude solid was purified by flash chromatography on silica gel (eluant: AcOEt/hexane:1/9) to afford 0.245 g (35% yield) of:

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude solid was purified by flash chromatography on silica gel (eluant: AcOEt/hexane:1/9)
  3. customto afford 0.245 g (35% yield) of:

Sources & evidence

ORD record
ord-fc95ef0a762c4f848958838da7431798
Source dataset
uspto-grants-2014_12
Patent number
US08916577B2

Reaction notes

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