Trifluoroacetic acid → HCID 86701836, compound

HRID 1406019Notes

Reaction equation

HRID 1406019 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[NH:11][C:12]([C:14]1[C:18]2[CH2:19][CH2:20][CH2:21][C:22]3[C:23](=[N:24][C:25]([NH:28][C:29]4[CH:41]=[CH:40][C:32]([C:33]([O:35]C(C)(C)C)=[O:34])=[CH:31][C:30]=4[O:42][CH3:43])=[N:26][CH:27]=3)[C:17]=2[N:16]([CH3:44])[N:15]=1)=[O:13])[CH3:2].[C:45]([OH:51])([C:47]([F:50])([F:49])[F:48])=[O:46]>C(Cl)Cl>[F:48][C:47]([F:50])([F:49])[C:45]([OH:51])=[O:46].[CH2:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([CH2:1][CH3:2])[C:4]=1[NH:11][C:12]([C:14]1[C:18]2[CH2:19][CH2:20][CH2:21][C:22]3[C:23](=[N:24][C:25]([NH:28][C:29]4[CH:41]=[CH:40][C:32]([C:33]([OH:35])=[O:34])=[CH:31][C:30]=4[O:42][CH3:43])=[N:26][CH:27]=3)[C:17]=2[N:16]([CH3:44])[N:15]=1)=[O:13])[CH3:10]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68295583HCID 68295583, compound

Product 1

HCID 86701836HCID 86701836, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-({3-[(2,6-diethylphenyl)carbamoyl]-1-methyl-1,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidin-9-yl}amino)-3-methoxybenzoate (0.450 g, 0.75 mmol) in DCM (6 mL), TFA (1 mL) was added. The mixture was stirred at room temperature for 2 hours. The organic solvent was evaporated to dryness to give the title compound in quantitative yield.

Workup

  1. customThe organic solvent was evaporated to dryness

Sources & evidence

ORD record
ord-823c53b6506f4453beab743de74ba317
Source dataset
uspto-grants-2014_12
Patent number
US08916577B2

Reaction notes

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