2,4-Dichlorophenol → HCID 86701843, compound

HRID 1406026Notes

Reaction equation

HRID 1406026 reaction equation
FC(F)(F)S([O:6][C:7]1[N:12]=[C:11]2[C:13]3[N:20]([CH3:21])[N:19]=[C:18]([C:22](=[O:27])[N:23]([O:25][CH3:26])[CH3:24])[C:14]=3[CH2:15][CH2:16][CH2:17][C:10]2=[CH:9][N:8]=1)(=O)=O.[Cl:30][C:31]1[CH:36]=[C:35]([Cl:37])[CH:34]=[CH:33][C:32]=1O>C1COCC1>[Cl:30][C:31]1[CH:36]=[C:35]([Cl:37])[CH:34]=[CH:33][C:32]=1[O:6][C:7]1[N:12]=[C:11]2[C:13]3[N:20]([CH3:21])[N:19]=[C:18]([C:22]([N:23]([O:25][CH3:26])[CH3:24])=[O:27])[C:14]=3[CH2:15][CH2:16][CH2:17][C:10]2=[CH:9][N:8]=1

Participants

4

Reactant 2

HCID 84492,4-DichlorophenolHCID 86701835HCID 86701835, compound

Product 1

HCID 86701843HCID 86701843, compoundYield 2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 3-[methoxy(methyl)carbamoyl]-1-methyl-1,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidin-9-yl trifluoromethanesulfonate (73 mg, 0.17 mmol) in THF (3 mL), 2,4-dichlorophenol was added in a microwave vial flushed with argon. The reaction mixture was stirred at 60° C. for 48 h. The solvent was removed under reduced pressure, the crude was purified by preparative HPLC to give 2 mg (2% yield) of the title compound.

Workup

  1. customvial flushed with argon
  2. customThe solvent was removed under reduced pressure
  3. customthe crude was purified by preparative HPLC

Sources & evidence

ORD record
ord-01b03f8e04ef4a81922710e99c896b4d
Source dataset
uspto-grants-2014_12
Patent number
US08916577B2

Reaction notes

Loading…