5-Bromofuran-2-carbaldehyde → HCID 86713724, compound

HRID 1406059Notes

Reaction equation

HRID 1406059 reaction equation
Br[C:2]1[O:6][C:5]([CH:7]=[O:8])=[CH:4][CH:3]=1.[F:9][C:10]([F:22])([F:21])[O:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[F:9][C:10]([F:21])([F:22])[O:11][C:12]1[CH:17]=[CH:16][C:15]([C@H:2]2[O:6][C@@H:5]([CH2:7][OH:8])[CH2:4][CH2:3]2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 6003285-Bromofuran-2-carbaldehydeHCID 27343864-(Trifluoromethoxy)phenylboronic acid

Product 1

HCID 86713724HCID 86713724, compound

Procedure

{cis-5-[4-(Trifluoromethoxy)phenyl]tetrahydrofuran-2-yl}methanol was prepared from 5-bromofuran-2-carbaldehyde and [4-(trifluoromethoxy)phenyl]boronic acid using a method analogous to that described in footnote 21.

Sources & evidence

ORD record
ord-f9fdc89f1db946f6ae2a46f98c93afac
Source dataset
uspto-grants-2014_12
Patent number
US08916564B2

Reaction notes

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