Diethyl Ether → Hydrochloric Acid

HRID 140617Notes

Reaction equation

HRID 140617 reaction equation
[CH2:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH:24]1[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]1.[CH2:30]([OH:31])[CH2:32][CH:33]([CH3:34])[CH3:35].[CH3:36][CH2:37][O:38][CH2:39][CH3:40].[NH2:1][c:2]1[n:3][c:4]([Cl:16])[n:5][c:6]2[c:7]([O:14][CH3:15])[c:8]([O:12][CH3:13])[cH:9][cH:10][c:11]12>>[ClH:16].[NH2:1][c:2]1[n:3][c:4]([N:27]2[CH2:26][CH2:25][CH:24]([CH2:17][c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[CH2:29][CH2:28]2)[n:5][c:6]2[c:7]([O:14][CH3:15])[c:8]([O:12][CH3:13])[cH:9][cH:10][c:11]12

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 31260Isoamyl AlcoholHCID 317384-BenzylpiperidineHCID 129200082-Chloro-4-amino-7,8-dimethoxyquinazoline

Product 2

HCID 313Hydrochloric AcidHCID 129200132-(4-Benzylpiperidin-1-yl)-7,8-dimethoxyquinazolin-4-amine

Sources & evidence

ORD record
ord-7fb37036479346be846aa5d7b7943b4d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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