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1-(5-Fluoro-2-methoxyphenyl)ethan-1-one → HCID 26597266、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(5-Fluoro-2-methoxyphenyl)ethan-1-one | HCID 2737356 | — |
| 反応物 | Chlorobis(2,6,6-trimethylbicyclo(3.1.1)heptan-3-yl)borane | HCID 13515837 | — |
| 反応物 | (S)-1-(5-Fluoro-2-methoxyphenyl)ethan-1-ol | HCID 14928684 | — |
| 反応物 | (-)DIP-Chloride | HCID 16212015 | — |
| 生成物 | HCID 26597266 | HCID 26597266 | — |
反応手順
The title compound was prepared, according to the method used to make (S)-1-(5-fluoro-2-methoxy-phenyl)-ethanol from 1-(5-fluoro-2-methoxy-phenyl)-ethanone (see H. C. Brown, Tet. Letts., 35 (14), 2141-4, 1994) except that (+)-DIP-Chloride™ was used instead of (−)-DIP-Chloride™, as a white crystalline solid (63%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08916593B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-b2b1310c2a664715a1645aa5e29b28c6 |
| 出典メモ | uspto-grants-2014_12 |