Hydrochloric Acid → HCID 86691098, compound

HRID 1406290Notes

Reaction equation

HRID 1406290 reaction equation
[CH3:1][C:2]1([CH3:25])[C:6]([CH3:8])([CH3:7])[O:5][B:4]([C:9]2[CH:14]=[CH:13][C:12]([C@H:15]([NH:17]C(=O)OC(C)(C)C)[CH3:16])=[CH:11][CH:10]=2)[O:3]1.[ClH:26]>C(Cl)Cl.O1CCOCC1>[ClH:26].[CH3:8][C:6]1([CH3:7])[C:2]([CH3:1])([CH3:25])[O:3][B:4]([C:9]2[CH:10]=[CH:11][C:12]([C@H:15]([NH2:17])[CH3:16])=[CH:13][CH:14]=2)[O:5]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67467206tert-Butyl (R)-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)carbamate

Product 1

HCID 86691098HCID 86691098, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

(R)-tert-butyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate (727 mg, 2.09 mmol) was dissolved in CH2Cl2 (4 mL) and a solution of HCl in dioxane (4M, 4 mL). The mixture was stirred at room temperature for overnight. LCMS indicated the reaction was complete. The reaction solution was concentrated in vacuo to afford the title compound as a white solid (1.00 g).

Workup

  1. concentrationThe reaction solution was concentrated in vacuo

Sources & evidence

ORD record
ord-f7840e8a86034b5c9cb4443d9cfc865c
Source dataset
uspto-grants-2014_12
Patent number
US08916593B2

Reaction notes

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