Potassium Carbonate → HCID 67465425, compound

HRID 1406297Notes

Reaction equation

HRID 1406297 reaction equation
[Br:1][C:2]1[C:3]([CH3:8])=[N:4][NH:5][C:6]=1[CH3:7].C([O-])([O-])=O.[K+].[K+].[CH3:15][S:16][CH2:17]Cl>CC(C)=O.C(Cl)Cl>[Br:1][C:2]1[C:3]([CH3:8])=[N:4][N:5]([CH2:15][S:16][CH3:17])[C:6]=1[CH3:7]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 16916Chloromethyl methyl sulfideHCID 769374-bromo-3,5-dimethyl-1H-pyrazole

Product 1

HCID 67465425HCID 67465425, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-bromo-3,5-dimethyl-1H-pyrazole (2.10 g, 14.3 mmol) in acetone (20 mL) was added K2CO3 (2.37 g, 17.1 mmol) followed by chloromethyl methyl sulfide (1.3 mL, 5.7 mmol). The light yellow suspension was stirred at room temperature for 96 hr. At this time the reaction was thick with white precipitate. The reaction mixture was stripped off volatiles, diluted with methylene chloride and filtered. The filtrate was concentrated under reduced pressure to give the title compound as a light yellow oil which was used without further purification.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-cf4f6b1daca34b57bb9d545482ae7c99
Source dataset
uspto-grants-2014_12
Patent number
US08916593B2

Reaction notes

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